| Total | 68 | 13 | (19%) | 18 | (26%) | 37 | (54%) |
| Home | 34 | 10 | (29%) | 12 | (35%) | 12 | (35%) |
| Away | 34 | 3 | (9%) | 6 | (18%) | 25 | (74%) |
L | 1981-06-06 | AZ Alkmaar |  | 1-0 |  | FC Wageningen | D34 | ||
L | 1981-05-31 | FC Wageningen | | 1-2 |  | FC Den Haag | D33 | ||
L | 1981-05-24 | FC Groningen |  | 2-0 | | FC Wageningen | D32 | ||
D | 1981-05-17 | FC Wageningen | | 0-0 |  | Excelsior | D31 | ||
L | 1981-05-10 | PSV |  | 4-0 | | FC Wageningen | D30 | ||
D | 1981-05-03 | FC Wageningen | | 2-2 |  | NAC Breda | D29 | ||
L | 1981-04-26 | Sparta Rotterdam |  | 3-0 | | FC Wageningen | D28 | ||
L | 1981-04-20 | Roda |  | 4-1 | | FC Wageningen | D27 | ||
W | 1981-04-12 | FC Wageningen | | 2-1 |  | Go Ahead Eagles | D26 | ||
L | 1981-04-05 | FC Utrecht |  | 5-0 | | FC Wageningen | D25 | ||
W | 1981-03-29 | FC Wageningen | | 2-1 |  | Willem II | D24 | ||
W | 1981-03-22 | FC Wageningen | | 3-0 | | FC Groningen | D15 | ||
L | 1981-03-15 | Feyenoord |  | 6-0 | | FC Wageningen | D23 | ||
L | 1981-03-08 | FC Wageningen | | 0-1 |  | FC Twente | D22 | ||
L | 1981-03-01 | MVV |  | 1-0 | | FC Wageningen | D21 | ||
L | 1981-02-15 | FC Wageningen | | 0-2 |  | Ajax | D20 | ||
D | 1981-02-08 | FC Wageningen | | 1-1 |  | NEC | D19 | ||
L | 1981-02-01 | Zwolle |  | 1-0 | | FC Wageningen | D18 | ||
L | 1980-12-21 | FC Wageningen | | 1-2 | | AZ Alkmaar | D17 | ||
L | 1980-12-14 | FC Den Haag | | 3-2 | | FC Wageningen | D16 |
